Endocrine Abstracts

Introduction: Interferon treatment for hepatitis C has been associated with Graves’-like thyroiditis, developing in rare instances severe ophthalmopathy. The usual management is interferon withdrawal and high-dose corticosteroids, but it may interfere with the resolution of hepatitis. Hereby we report a case successfully treated with radiotherapy, which in our knowledge has never been previously reported.Case report: A 52-year-old woman was diagnose...

Aim: To evaluate whether differences exist in terms of patient, radiological, tumour characteristics and surgical complications between malignant and benign thyroidectomy.Materials and methods: 184 correlatives cases of thyroidectomy during the period from October 2011 to October 2013 are analysed. Patient, ultrasound, tumour and complication characteristics are compared. Categorical data are reported as percentages. Characteristics between the two group...

Introduction: The prevalence of hyperthyroidism in patients admitted in Internal Medicine at Spanish hospitals is 0.8%. Proper diagnosis and management of HTD in these patients is still a challenge and therefore, the analyses of the factors involved in the prognosis and survival is of interest.Methods: Data from the minimum-data-set (MDS) of Spanish National health System were collected during 2005–2012 from discharged patients of Internal Medicine ...

Introduction: Even though pituitary apoplexy usually occurs in the context of a pituitary adenoma, it can also occur over other tumours, which is less common in adulthood and has faster growth and aggressiveness. It can also produce clinical, analytical and even radiological indications that are indistinguishable from a pituitary adenoma with ischemic and/or haemorrhagic events.Case report: A 43-year-old female, with no medical history of interest except...

Background: IGF1 is mainly produced in the liver and it induces beneficial effects on many systems. However, the role of IGF1 on the liver itself is poorly understood, probably due to the fact that healthy hepatocytes barely express IGF1 receptors. Previous works in our group showed that IGF1 supplementation induces beneficial actions in cirrhosis, inducing a relevant histological improvement, reducing fibrosis1. Based on these data the aim of this work was to inqui...

Background: IGF1 is mainly produced in the liver and it induces beneficial effects on many systems. However, the role of IGF1 on the own liver is poorly understood, probably due to the fact that healthy hepatocytes barely express IGF1 receptors. Previous works in our group showed that IGF1 supplementation induces beneficial actions in cirrhosis, including antioxidant, anti-inflammatory and antifibrogenic effects. Based on these data the aim of this work was to deep into the me...

Background and aims: Obesity is linked to a low-grade and chronic systemic inflammation that improves after a significant weight loss. In the same way, depressive disorder has been suggested to be associated with systemic inflammation up regulation. We aimed to explore whether, after a significant weight loss, the presence of depressive symptoms was associated with differences in terms of inflammatory markers and quality of life compared with individuals without significant de...

Introduction: MicroRNAs (miRNAs) are short non-coding RNAs that regulate translation or degradation of target mRNAs. Therefore, miRNAs control gene expression in many biological processes, including proliferation, apoptosis, and differentiation. Deregulation of miRNAs expression is an important contributor to tumour development and progression. Even though several genetic and epigenetic lesions have been identified in human thyroid cancer, particularly in the papillary histoty...

A 28-year-old woman presents with a one-year history of marked weight gain of 18 kg, increasing hirsutism and night sweats. Clinically, hyperandrogenism and Cushing’s syndrome were suspected. A diagnosis of Polycystic ovarian syndrome was made based on Rotterdam criteria and Metformin was initiated. Initial testing for Cushing’s syndrome demonstrated a high 24 h urinary free cortisol (306 nmol/l) with incomplete cortisol suppression on an overnight dexamethaso...

Introduction: Hypoparathyroidism (hypoPT) is the most frequent complication after thyroid surgery, usually as transient hypocalcaemia. Permanent parathyroid lesion is less frequent, but it can extend hospital stay and complicate postoperative management. Several preoperative factors predicting the development of hypoPT have been identified, including advanced age, hyperthyroidism, surgical experience and others. We evaluate the role of some potentially predictive factors in ou...